{
  "id": "lib-process:bioinformatics--clinical-variant-interpretation",
  "_kind": "LibraryProcess",
  "_file": "generated-library/processes.yaml",
  "_cluster": "generated-library",
  "attributes": {
    "displayName": "clinical-variant-interpretation",
    "description": "Clinical Variant Interpretation - Systematic process for interpreting genetic variants\naccording to ACMG/AMP guidelines for clinical reporting. Includes pathogenicity classification,\nevidence curation, and report generation.",
    "libraryPath": "library/specializations/domains/science/bioinformatics/clinical-variant-interpretation.js",
    "specialization": "bioinformatics",
    "references": [
      "- ACMG/AMP Guidelines: https://www.nature.com/articles/gim201530\n- ClinGen: https://clinicalgenome.org/\n- ClinVar: https://www.ncbi.nlm.nih.gov/clinvar/\n- gnomAD: https://gnomad.broadinstitute.org/"
    ],
    "example": "const result = await orchestrate('specializations/domains/science/bioinformatics/clinical-variant-interpretation', {\n  projectName: 'Rare Disease Case Review',\n  variants: [{ gene: 'BRCA1', hgvs: 'c.5266dupC' }],\n  phenotype: 'Breast cancer, early onset',\n  inheritancePattern: 'autosomal-dominant'\n});",
    "usesAgents": [
      "general-purpose"
    ]
  },
  "outgoingEdges": [
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "skill-area:data-analysis",
      "kind": "lib_requires_skill_area",
      "attributes": {
        "weight": 1
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "skill-area:statistical-analysis",
      "kind": "lib_requires_skill_area",
      "attributes": {
        "weight": 0.7
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "skill-area:python-data-pipelines",
      "kind": "lib_requires_skill_area",
      "attributes": {
        "weight": 0.5
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "domain:bioinformatics",
      "kind": "lib_applies_to_domain",
      "attributes": {
        "weight": 1
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "role:research-engineer",
      "kind": "lib_involves_role",
      "attributes": {
        "weight": 1
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "role:biomedical-engineer",
      "kind": "lib_involves_role",
      "attributes": {
        "weight": 0.7
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "workflow:experiment-design",
      "kind": "lib_implements_workflow",
      "attributes": {
        "weight": 1
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "specialization:biomedical-informatics",
      "kind": "lib_belongs_to_specialization",
      "attributes": {
        "weight": 1
      }
    },
    {
      "from": "lib-process:bioinformatics--clinical-variant-interpretation",
      "to": "specialization:bioinformatics",
      "kind": "lib_belongs_to_specialization",
      "attributes": {
        "weight": 0.9
      }
    }
  ],
  "incomingEdges": []
}